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This process is influenced by oxidative stress, resulting from an imbalance in the body's antioxidant system [31], as well as hyperglycemiainduced protein glycosylation, which exacerbates tendon fibrosis and diminishes elasticity [32]

A 2020 research review looking at 12 berberine studies found that the supplement is associated with a modest but significant lowering effect on participants body weight, body mass index, and waist circumference

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